Brown -- who leads the Giants with eight rushing touchdowns -- likely will miss the rest of the season after leaving Sunday's win over the Green Bay Packers early in the fourth quarter.
An eight-week stay on the IR list means Brown could eligible to return this season only if New York reaches Super Bowl XLVII.
The 25-year-old has picked up 385 yards on 73 carries this season, including 64 yards on 13 attempts in Sunday's win.
He has served as the main backup to leading rusher Ahmad Bradshaw.
Britney Spears talks pregnancy sex, lip injections and Kim Kardashian
Campus cop fatally shoots Texas student during traffic stop