Manning shook off an interception early in the contest, finishing 22-of-37 through the air for 285 yards as the AFC West-leading Broncos improved to 8-3.
Brady Quinn managed just 126 yards on 13-of-25 efficiency for the reeling Chiefs (1-10), who fell to 0-6 at home for the first time since 1976.
Jamaal Charles picked up 107 yards on 23 carries for Kansas City.
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