Deron Williams contributed 15 and 12 assists as Brooklyn recorded a second straight victory.
Brook Lopez (15 points, eight rebounds) and Kris Humphries (14, 10) helped out with double-doubles, and Andray Blatche provided 13 points and eight boards for Brooklyn.
The Trail Blazers, meanwhile, began a seven-game road trip on a losing note despite 20 points from Wesley Matthews.
J.J. Hickson donated 19 and 10 rebounds for Portland.
Susan Sarandon 'very excited' about daughter's pregnancy
Dennis Rodman pledges to end trips to North Korea