Bryant scored 10 of his points in the final 5 minutes as the Lakers erased a six-point deficit and went on a 17-6 run to end the game, nosing above .500 (6-5) for the first time this season.
D'Antoni, named the Lakers new coach Nov. 12, had missed the two games since the announcement while recovering from knee replacement surgery but was behind the bench Tuesday as Los Angeles racked up its fifth win in six contests.
Metta World Peace chipped in 17 points and eight boards for the Lakers.
Brook Lopez netted 23 points with seven rebounds and Deron Williams added 22 points and 10 assists for Brooklyn, which fell to 2-2 on the road.
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