George hit nine 3-pointers overall and Roy Hibbert contributed his first career triple-double in the Pacers' second straight victory. New Orleans has lost five in a row
The Hornets tied it with 22 seconds to go in regulation on a jump shot by Al-Farouq Aminu, but they could not gain any momentum in the extra period.
George hit a 3-pointer 14 seconds into overtime and Hill made another to give the Pacers a 103-97 lead.
George hit three 3-pointers down the stretch of regulation and he scored 33 of his career-best 37 points in the second half and overtime.
Hibbert blocked 11 shots, a franchise record, grabbed 11 rebounds and scored 10 points. Hill and Davis West both had 16 points for the Pacers.
Robin Lopez scored a season-best 21 points and grabbed 13 rebounds for New Orleans.