The Cavaliers ended a six-game losing streak, opening a 13-point lead after one period and holding on for the rest of the contest.
Philadelphia climbed within 80-77 with 3:35 to go on a jumper by Jrue Holiday, but a Pargo layup started a 12-6 burst that concluded the game. He added a 3-pointer that gave the Cavaliers a 90-77 lead inside the 2-minute mark.
Dion Waiters had 16 points for Cleveland and Alonzo Gee added 14. Philadelphia had defeated Cleveland on Sunday 86-70.
The Cavaliers' victory was only their third of the season.
Holiday and Jason Richardson had 16 points each for Philadelphia, which had won three in a row.