D'Antoni was scheduled to coach his first game Sunday but put it off as he continues to recover from knee replacement surgery earlier this month.
Los Angeles fell behind 11-6 in the early going but then outscored the Rockets 34-18 to finish the first quarter and never trailed after that.
Pau Gasol added 17 points, Metta World Peace put in 15 and Darius Morris contributed 12 for Los Angeles, which shot 54.1 percent from the field.
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