Brees went 20-of-27 for 219 passing yards and hooked up twice with Lance Moore for scoring strikes as the Saints (5-5) got back into the NFC playoff hunt with their third straight win and fifth in six games.
Jimmy Graham led the Saints' receiving corps, logging a touchdown on six grabs for 29 yards. Mark Ingram picked up 67 rushing yards with a score.
The Raiders (3-7), meanwhile, fell for the third straight time despite 312 yards on 22-of-40 efficiency from Carson Palmer, who was intercepted twice.
Marcel Reece ran for 103 yards on 19 carries for Oakland.
Wisconsin business offering 'therapeutic cuddling' forced to close
Exploding whale video goes viral on Internet