Anthony put in 25 points while J.R. Smith and Raymond Felton added 21 apiece for the Knicks, who improved to 5-0 for the second-best start in franchise history.
Tyson Chandler helped out with 12 points and six rebounds as New York broke open a close game with a big fourth quarter during which it outscored the Magic 22-13.
J.J. Reddick scored 18 points to go with seven assists while Nikola Vucevic supplied 12 points and 10 boards for Orlando, which dropped a fifth straight.
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