Wilson went 12-of-19 for 188 passing yards and Marshawn Lynch ran for 124 yards with a score as the Seahawks (6-4) remained undefeated at home.
New York (3-6), meanwhile, continued its worst start since 2007 as Mark Sanchez completed just 9-of-22 throws for 124 yards with an interception in the end zone.
Sanchez also surrendered a fourth-quarter fumble for the struggling Jets, who lost their third straight and fifth in six games overall.
Muhammad Wilkerson recovered a fumble for a score in the first quarter, providing the only points for New York.
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