The Pistons have the worst early season record in the NBA at 0-6 and are one of just two winless teams left in the league. Washington dropped to 0-4 earlier in the evening.
Durant scored 25 points and grabbed 13 rebounds. Ibaka matched Durant with 25, the most he has produced in his four-year career.
Eric Maynor added 13 points for the Thunder, who shot 53 percent from the field. Oklahoma City has defeated Detroit in each of their last seven meetings.
The Pistons got 22 points and eight rebounds from rookie Andre Drummond. Detroit is off to its worst start in 32 seasons.
Detroit was within five early in the fourth quarter before Oklahoma City went on a 14-3 run that put the game away.