George put in 20 points to go with seven rebounds. Green contributed 15 points and eight boards.
Lance Stephenson (12 points) and David West (11) also reached double figures as the Pacers broke a three-game losing streak.
The Wizards fell to 0-5 to begin the season despite 17 points each from Emeka Okafor and Bradley Beal.
A.J. Price provided 12 and 14 rebounds for Washington.