The Bulls improved to 6-0 in their last six meeting against the Timberwolves with the help of Joakim Noah, who put in 17 points and grabbed seven rebounds.
Luol Deng turned in an all-around game with 16 points, seven boards and four assists for the Bulls.
The Timberwolves, meanwhile, saw their three-game winning streak snapped despite 18 points and eight rebounds from Nikola Pekovic.
Minnesota's Andrei Kirilenko helped out with 11 points, 12 boards and seven assists.
Duggar sisters unveil Christian dating rules in new book
LGBT community has 'bullied the American people': Bachmann