The Bulls improved to 6-0 in their last six meeting against the Timberwolves with the help of Joakim Noah, who put in 17 points and grabbed seven rebounds.
Luol Deng turned in an all-around game with 16 points, seven boards and four assists for the Bulls.
The Timberwolves, meanwhile, saw their three-game winning streak snapped despite 18 points and eight rebounds from Nikola Pekovic.
Minnesota's Andrei Kirilenko helped out with 11 points, 12 boards and seven assists.
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