Wie has finished among the Top 20 just twice all season. The 66 was her lowest score since the second round of this year's U.S. Women's Open.
The 36-player field is taking part in the next-to-last event of the year on the LPGA Tour. The Titleholders tournament will conclude the season's action next week in Naples, Fla.
This is Wie's 22nd event of the year and she has missed the cut 10 times. She played a bogey-free round that was highlighted by four straight birdies starting at the par-5 10th.
Tournament host Lorena Ochoa shot a 1-under 71 and was tied for 16th place.
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