Westbrook put in 19 points and dished off eight assists. Ibaka supplied 17 points on 8-of-9 shooting as the Thunder improved to 2-2 on the season.
The Raptors were paced by rookie center Jonas Valanciunas, who struck for 18 points, and by Andrea Bargani's 16-point performance.
Toronto fell for the third time in four games.
2014 amfAR Inspiration Gala [PHOTOS]
Julius Randle breaks leg during NBA debut