Grassy finished second and Atigun, who led into the stretch, finished third. The favorite, veteran international campaigner Fame and Glory, clearly did not like his first start on a dirt track and jogged home at the back of the field.
Calidoscopio, a 9-year-old Argentine-bred, got the 1 3/4 miles on a fast track in 2:57.23 with Aaron Gryder riding for his first-ever Breeders' Cup win.
Calidoscopio, trained by Guillermo Frankel, had 39 previous starts, 38 of them in Argentina and one in Chile. He had won nine of those.