Ryan connected on all three of his TD tosses in the first half, going 17-of-20 through the air for 197 yards during the span. He finished with 262 yards as the Falcons (7-0) remained the NFL's only remaining unbeaten squad.
Julio Jones led the Atlanta receiving corps with five receptions for 123 yards and a touchdown.
Michael Vick was held to 21-of-35 passing efficiency for 191 yards and a score for Philadelphia (3-4).
LeSean McCoy provided a rushing and receiving touchdown for the Eagles, who were coming off a bye week.