Locker, a second-year pro, was injured in the first quarter of last week's game against Houston. He was helped from the field and later appeared on the sidelines with his left -- non-throwing -- arm in a sling.
It was determined Locker dislocated his left shoulder. It was the second time in four games he suffered the same injury.
Locker has completed 67-of-106 passes for 781 yards and four touchdowns this season. He also was intercepted twice.
Matt Hasselbeck is expected to start at quarterback for the Titans (1-3) when they play the Vikings (3-1) in Minnesota.