Chicago lost its third in a row and fell two games behind Detroit in the race for the American League Central title. The Rays trail Oakland by 1 1/2 games for the league's second wild card berth.
The game had been deadlocked at 2-2 since the fifth when Longoria came up in the ninth against reliever Brett Myers (3-8). Longoria launched a 2-1 pitch over the wall in left for his 14th homer.
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