The Chiefs (1-2) -- who scored the final 21 points of the game -- got a franchise-record 91-yard touchdown run from Jamaal Charles, who ended with 233 yards on 33 carries.
Matt Cassel compiled 248 yards and one interception on 26-of-44 passing efficiency.
New Orleans fell to its first 0-3 start since 2007 despite 240 aerial yards and three touchdowns from Drew Brees, who completed 20-of-36 passes.
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