Kolb, who was traded to the Cardinals from the Eagles in August 2011, racked up 222 yards on 17-of-24 passing as Arizona raced out to a 24-0 first-half lead.
Michael Vick was held to 217 yards, completing 17-of-37 passes for the Eagles (2-1).
LeSean McCoy led Philadelphia's rushers with 13 carries for 70 yards.
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