Maclin was hurt in the first game of the season but played last week until the injury was aggravated. He was taken off the field on a cart.
Maclin has seven receptions for 96 yards and one of the Eagles' two receiving touchdowns this year, as Philadelphia has started the year 2-0.
The Eagles also said left tackle King Dunlap, who left last week's game with a hamstring injury, and wide receiver Riley Cooper, who has an injured collarbone, will also be out this week.
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