Vick dove into the end zone with 1:55 left in the contest, erasing a 23-17 deficit after guiding the Eagles on a 10-play, 80-yard scoring drive.
The winning play almost wasn't, however -- an apparent Vick fumble on the preceding play was overturned after a video review.
Philadelphia (2-0) sealed the win when Joe Flacco's desperation pass on fourth-and-1 with 57 seconds left went out of bounds.
Vick finished 23-of-32 passing for 371 yards, one TD toss and two interceptions, while carrying the ball 10 times for 34 yards.
Tight end Brent Celek hauled down eight passes for 157 yards and DeSean Jackson made seven grabs for 114 yards.
Flacco completed 22-of-42 passes for 232 yards, a TD and an interception for the Ravens (1-1).
Ray Rice gained 99 yards on 16 carries for Baltimore.
Couple mistakenly served bag of cash at McDonald's drive-thru
Kate Middleton recycles dress at movie premiere