Nova (12-7) allowed two runs on four hits and two walks while striking out eight.
After Boone Logan coughed up a run, Joba Chamberlain and David Robertson combined for 1 2/3 scoreless frames and Rafael Soriano survived a hit and a walk in the ninth to nail down his 39th save as the Yankees evened their three-game set.
Curtis Granderson socked his 39th homer -- a two-run shot -- and Eduardo Nunez contributed a bases-empty blast for New York, which came into the contest tied with Baltimore for the top spot in the American League East.
James Shields (14-9) was saddled with the loss, yielding four runs on six hits over 6 1/3 frames.
2014: NFL Cheerleaders [PHOTOS]
Michael Sam cut from the Dallas Cowboys