Sanchez went 19-of-27 through the air, racking up 266 yards, while finding rookie wide receiver Stephen Hill twice with scoring strikes for New York (1-0).
Buffalo (0-1) got three touchdown passes from Ryan Fitzpatrick, but the signal-caller also yielded a trio of interceptions.
C.J. Spiller ran for 169 yards with a touchdown yards on 14 carries in the setback.
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