Ryan racked up 299 aerial yards and completed six passes to Julio Jones, who finished with 108 yards and two touchdowns.
Tony Gonzalez haunted his former team with a TD grab for the Falcons (1-0).
The Chiefs (0-1) were led by Matt Cassel, who compiled 258 yards on 21-of-33 passing efficiency -- but was picked off twice.
Dexter McCluster hauled in six receptions for 82 yards and Kevin Boss made a 22-yard TD grab for Kansas City.
Celebrity Families of 2014 [PHOTOS]