Creamer -- whose most recent victory came at the 2010 U.S. Women's Open -- used a steady hand to grab the top spot at 16-under 197 after 54 holes.
That was two better than second-round leader Jiyai Shin, who stayed in the hunt with a 2-under 69 Saturday at Kingsmill Resort.
Dewi Claire Schreefel (69) and Danielle Kang (70) shared third place at minus-12.
Boston schools pull out free condoms over wrapping complaints
Aaron Carter is still in love with Hilary Duff