Medlen (7-1), making his seventh start of the year to go along with 38 relief appearances, allowed only one unearned run and didn't issue a walk in the dominating performance.
The victory came after the right-hander had fanned nine over eight innings of five-hit ball Tuesday in a 2-0 win at San Diego.
Colorado starter Tyler Chatwood (4-4) was tagged for six runs on three hits in a three-inning effort.
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