Ortiz has been hobbled by a right Achilles strain. The move to the Red Sox disabled list is retroactive to Aug. 25. He was on the DL from July 17-Aug. 23 for the same injury.
Ortiz is hitting .318 with 23 home runs and 60 runs batted in over 90 games this season.
Matsuzaka, who hadn't pitched since July 2 because of a muscle strain in his right shoulder, got the start Monday against the Royals and pitched seven innings in a 5-1 victory.