The Jaguars will be taking the place of the St. Louis Rams, who had agreed to play a series of games in London but recently withdrew due to issues regarding the Edward Jones Dome in St. Louis.
The Rams will play the New England Patriots Oct. 28 in London's Wembley Stadium but pulled out of overseas games in 2013 and 2014.
Jaguars officials said they'd take the NFL's London games in 2013-16.
"The Jacksonville Jaguars will be a bold and ambitious NFL franchise," Jaguars Owner Shad Khan said. "Playing a home game in London over four seasons is consistent with our vision to introduce and grow the Jaguars brand globally.
"This is a priceless opportunity to share the business, tourism and lifestyle story of Jacksonville with international audiences, and I know it will give the Jaguars a unique and powerful identity within the league and beyond."