Wilson, playing in the second half, completed 10-of-17 passes.
Tyrell Sutton and Cooper Helfet each hauled down a Wilson scoring strike in the fourth quarter to seal the win.
Matt Flynn started the game behind center for Seattle and went 6-of-13 through the air for 31 yards.
The Chargers' Peyton Manning made his second start of the pre-season and went 16-of-23 passing for 177 yards and two interceptions in the first half.
Denver's Willis McGahee gained 28 yards on eight carries.
Reindeer recovered after escaping from Santa during lighting ceremony
Ukrainian protestors topple Lenin statue [VIDEO]