Wilson, playing in the second half, completed 10-of-17 passes.
Tyrell Sutton and Cooper Helfet each hauled down a Wilson scoring strike in the fourth quarter to seal the win.
Matt Flynn started the game behind center for Seattle and went 6-of-13 through the air for 31 yards.
The Chargers' Peyton Manning made his second start of the pre-season and went 16-of-23 passing for 177 yards and two interceptions in the first half.
Denver's Willis McGahee gained 28 yards on eight carries.