Eli Manning went 7-of-14 through in the air while playing the entire the first half, tossing for 62 yards and an interception.
Victor Cruz hauled down five passes for 51 yards.
Giants running back Ahmad Bradshaw sustained a hand injury and backup D.J. Ware replaced him, gaining 15 yards on 11 carries.
The Jets' Mark Sanchez racked up 59 yards on 9-of-11 passing, while Tim Tebow, making his first appearance for New York, went 5-of-14 for 69 yards in the second half.