Huston finished the day at 12-under-par 132, one shot better than Brad Faxon through 36 holes at the En-Joie Golf Club on a day when both the first and second rounds were completed due to Friday's rain.
The 51-year-old will be seeking his second overall Champions Tour crown Sunday.
Faxon grabbed second place at 11-under 133 after firing a 66 in the second round.
Tied for third at minus-9 were Willie Wood (68) and Peter Senior (67).
Notable deaths of 2014 [PHOTOS]