Hamels (13-6) allowed only one runner to reach as far as third base in the performance, during which he tossed 85 of his 113 pitches for strikes.
The left-hander scattered seven hits, issued one walk and struck out five as the Phillies claimed the opener of a three-game series.
Miami's Nathan Eovaldi (3-8) was tagged with the loss, though only two of the three runs he allowed through five innings were earned. He gave up eight hits.
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