Former Green Bay Packer Flynn, who signed a three-year contract with Seattle in the off-season, went 6-for-6 in the opening drive and tossed one interception.
Rookie Russell Wilson played the second half, amassing 124 yards and a touchdown on 12-of-16 passing with one interception. The former Wisconsin star also ran 32 yards for a touchdown late in the fourth quarter.
Tennessee's Matt Hasselbeck, who played for Seattle for 10 years, returned to the city as an opponent for the first time and finished 5-of-9 for 45 yards and two interceptions.
Jake Locker completed 7-for-13 passes for 80 yards for the Titans.