Manning, who missed last season with a neck injury, threw an interception in the only series he played for the Broncos but finished the night 4-for-7 passing for 44 yards.
Adam Weber and Brock Osweiler threw touchdown passes for the Broncos, and Lance Ball and Xavier Omon scored on the ground.
Chicago's lone score came on a 47-yard field goal by Robbie Gould in the fourth quarter. The Bears ended up with 132 net yards of offense to Denver's 338 and were 0-for-11 on third-down conversions.
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