Richard (8-11) work around eight hits and a pair of walks and the Padres infield turned three double plays in the opener of a three-game series.
Chris Denorfia and Yonder Alonso each drove in a run for San Diego.
New York's R.A. Dickey (14-3) was saddled with the loss, surrendering three runs (two earned) on four hits over seven innings.
Ronny Cedeno went 2-for-3 with an RBI for the Mets.
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