Jonathan Lucroy chipped in with a two-run blast as Milwaukee banged out 15 hits in the victory.
Mike Fiers (5-4) held Houston to two runs on eight hits over six innings to pick up the win. He didn't issue a walk and struck out six.
Astros starter Jordan Lyles (2-8) was rocked for nine runs (seven earned) on nine hits through a five-inning effort.
Brett Wallace cracked a pair of homers while going 3-for-4 as the major league-worst Astros fell to 1-22 in their last 23 road games.
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