Rodriguez, the all-time leader in home runs among active players, was hit by a pitch during Tuesday's game in Seattle. He was the third batter hit by Mariners' pitcher Felix Hernandez in a five-batter span.
Rodriguez, 36, is hitting .276 with 15 home runs and 44 runs batted in over 94 games this season. He has 644 home runs in his career, which is fifth most all time.
The Yankees recalled infielder Ramiro Pena from Triple A Scranton/Wilkes-Barre to fill the vacant roster spot. Earlier this season Pena appeared in 23 games with New York, hitting .100 with one home run and four RBI.