Roddick, seeded fourth in the event, dropped the first set 1-6, edged the stubborn Muller 7-6 (7-2) in the middle set and then put him away 6-2 in the deciding set for the 32nd win of his career.
The former world No. 1 took his other 2012 victory last month at Eastbourne.
Muller, who fell to 1-4 lifetime against Roddick, was done in by 10 double faults.
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