Arencibia's three-run blast in the second inning sealed the victory, putting Toronto ahead 8-3, while Rajai Davis (3-for-4, two RBI), Brett Lawrie and Travis Snider (three RBI) also went deep for the Blue Jays.
Yunel Escobar went 3-for-4 with two runs scored as Toronto banged out 18 hits to complete the three-game sweep at Fenway Park, during which they outscored Boston 28-11.
Henderson Alvarez (6-7) earned the victory despite surrendering seven runs on eight hits in a 5 2/3-inning effort.
Bosox starter Jon Lester (5-8) was lit up for 11 runs on nine hits over four full innings.
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