The United States shot 60.3 percent from the floor and was helped by 27 turnovers from Great Britain. The Americans were able to convert the turnovers for a total of 33 points.
Luol Deng paced Great Britain with 25 points while Pops Mensah-Bonsu chipped in 12 points and eight rebounds.
The United States has an exhibition Sunday against Argentina in Barcelona. The Americans start Olympic play July 29 versus France.
Thursday's win pushed the U.S. team's exhibition record to 40-1 since the 1992 Dream Team first took the floor.