Wright connected for a two-run home run in the first and a three-run shot in the fourth while the Mets were building a 9-1 lead off Washington's Gio Gonzalez (12-5).
Gonzalez was charged with six runs -- all earned -- on six hits walked walking three in 3 1/3 innings.
New York starter R.A. Dickey (13-1) scattered 10 hits and a walk over 7 1/3 innings n matching Tampa Bay's David Price for the major-league lead in wins. Price picked up his 13th win earlier Thursday.
After Wright staked the Mets to a 2-0 lead in the first, the Nationals got a home run from Ryan Zimmerman. But New York added an Ike Davis home run in the second, two runs in the third, with Davis driving in the second, for a 5-1 edge.
Josh Thales walked and scored on a Ruben Tejada single before Andres Torres also walked the next inning. Wright followed with a shot to straight-away center for his 14th home run of the season and a 9-1 lead.