The NL struck for five runs off AL starter Justin Verlander (0-1) of the Detroit Tigers in the first to put the game away early.
Verlander struck out Cincinnati's Joey Votto, but San Francisco's Sandoval followed by ripping a pitch into the right-field corner, scoring all three runners.
Sandoval then came home on an RBI hit from Atlanta's Dan Uggla to cap the big frame.
Cabrera -- who was named MVP -- added a two-run homer for the NL, which forged its biggest lead ever in an All-Star Game at 8-0 and logged its third straight win in the Mid-Summer Classic, securing home field advantage in the World Series.
San Francisco's Matt Cain (1-0) earned the victory with two scoreless frames as the NL posted the first All-Star Game shutout since 1996.
The AL could manage only six singles.