Lohse (9-2) yielded a two-run homer to Justin Ruggiano in the second inning, but that was it, otherwise limiting the Marlins to one walk while striking out four.
The Cardinals right-hander won his third straight start, registering his fourth consecutive appearance in which he's held his opponent to two or fewer runs.
Mitchell Boggs hurled a scoreless eighth inning and Jason Motte collected his 20th save despite allowing two hits in the ninth for the Cards, who evened their three-game series.
Carlos Zambrano (4-7) was touched for three runs on seven hits over five innings for the Marlins.
Notable deaths of 2014 [PHOTOS]