Pistorius will be the first athlete to compete in both the Summer Olympics and Paralympics, Sports Net reported. He was selected as a member of the 4X400 relay team and a competitor in the 400 meters.
"Today is truly one of the proudest days of my life," Pistorius said in a statement. "To have been selected to represent Team South Africa at the London 2012 Olympic Games in the individual 400 meters and the 4x400-meter relay is a real honor and I am so pleased that years of hard work, determination and sacrifice have all come together."
Pistorius, 25, was born with a congenital condition that left him without the fibula or calf bone in both legs. His legs were amputated in childhood.
A sports star since his school days, Pistorius has been dogged by arguments that his prosthetics actually give him an unfair advantage over other athletes.
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