Salvador Perez went 2-for-4 with a two-run shot and Yuniesky Betancourt added a pair of run-scoring singles for Royals, who banged out 14 hits in the opener of a four-game series.
Everett Teaford (1-1) earned the victory, allowing three runs on five hits while walking two and striking out two over seven innings.
Blue Jays starter Ricky Romero (8-3) was rocked for eight runs on 11 hits through six innings.
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