The fourth-seeded Murray beat Marcos Baghdatis of Cyprus by a 7-5, 3-6, 7-5, 6-1 margin. Tsonga reached the round-of-16 for a third straight year by besting Slovakian Lukas Lacko 6-4, 6-3, 6-3.
Ferrer, meanwhile, knocked off perennial U.S. contender Andy Roddick in four sets. The 30th-seeded Roddick, who has been runner-up at the tournament three times, was ousted by Ferrer 2-6, 7-6 (8), 6-4, 6-3 in a match in which each player won more than 110 points.
Ferrer earned a berth in the next round against ninth-seeded Juan Martin del Porto. The Argentine beat No. 19 seed Kei Nishikori of Japan 6-3, 7-6 (7-3), 6-1.
France's Tsonga will face 10th-seeded American Mardy Fish, who chalked up 17 aces in his three-set win over Belgian qualifier David Goffin.
Murray next goes up against 16th-seeded Croat Marin Cilic, who outlasted American Sam Querrey 7-6 (8-6), 6-4, 6-7 (2-7), 6-7 (3-7), 17-15 in 5 1/2 hours -- the second-longest match in Wimbledon history.
Wimbledon came to an early end Saturday for Czech qualifier Lukas Rosol, who stunned Rafael Nadal Thursday. Rosol lost in straight sets to Philipp Kohlschreiber of Germany.