Nieves launched a two-run blast in the fifth inning and Fowler (3-for-4) followed with a solo shot that put the Rockies ahead 11-1.
Rex Brothers (3-2) picked up the win with two innings of shutout ball after starter Josh Outman and reliever Adam Ottavino had allowed the Rangers seven runs through five frames.
Texas starter Colby Lewis (6-6) was bombed for eight runs (seven earned) on 11 hits before being knocked out after four full frames.
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