James, who was named the 2012 NBA MVP Saturday, responded with a big game for the Heat, who drew first blood in their best-of-seven, second-round Eastern Conference series with the Pacers.
Dwyane Wade added 29 points for the second-seeded Heat, who broke open a close game with an 8-2 run to start the fourth quarter and notched their 13th straight home playoff win against a conference foe.
Miami forward Chris Bosh exited the game with an abdominal strain late in the first half after scoring 13 points.
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